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. 2020 Sep 16;12(9):2647. doi: 10.3390/cancers12092647

Figure 7.

Figure 7

Combination of BOLD-100 and olaparib suppressed growth of TNBC xenografts. (A) Box and whisker plot showing distribution of tumor volume in each group of nude mice with MDA-MB-231 xenografts on Day 24 after treatment. Tumors treated with the combination of 50 mg/kg BOLD-100 and olaparib showed a 63% tumor growth inhibition (TGI), (TGI > 60% suggest a potential therapeutic activity), that differed significantly (* p ≤ 0.05, Mann–Whitney test) from vehicle or olaparib monotherapy but was not significantly different from BOLD-100 50 mg/kg. ns, not significant. (B) The mean tumor volumes in each treatment group were plotted as a function of time (days). For both graphs, colors are: vehicle (black), 30 mg/kg BOLD-100 (blue), 50 mg/kg BOLD-100 (green), olaparib (red), 30 mg/kg BOLD-100+olaparib (grey) and 50 mg/kg BOLD-100+olaparib (purple).