Table 1.
Reserve phase protein array (RPPA) results with significantly altered proteins in MCF7 cells treated with 100 μM BOLD-100 compared with control.
| PROTEIN NAME | p-Value | ≥20% Difference in 100 μM BOLD-100 Treated Cells |
|---|---|---|
| PDK1 | <0.001 | 24% increased |
| TSC1 | <0.001 | 27% increased |
| SOD2 | <0.001 | 22% increased |
| G6PD | <0.001 | 39% increased |
| HER2 | 0.002 | 31% increased |
| PDK1_pS241 | 0.004 | 35% increased |
| Notch1 | 0.006 | 21% increased |
| TFAM | 0.006 | 30% increased |
| PR (Progesterone receptor) | 0.009 | 64% decreased |
| DJ1 | 0.010 | 24% increased |
| MUC1 (EMA) | 0.014 | 65% increased |
| UGT1A | 0.015 | 36% increased |
| Collagen-VI | 0.025 | 21% increased |
| c-Jun_pS73 | 0.026 | 20% decreased |
| ATRX | 0.031 | 24% decreased |
| LC3A-B | 0.035 | 21% increased |
| Cyclin-D3 | 0.044 | 39% increased |