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Schematic overview of the classical CAR formats used in clinical trials treating solid tumors. The number of clinical trials using a specific CAR format is indicated. Data was extracted from clinicaltrials.gov. TM = transmembrane domain, iCASP9 = inducible caspase 9, 4SCART = fourth generation safety CAR-T cells. The Motifolio Scientific Illustration Toolkit was used for the generation of parts of this figure.
