Table 1.

Summary of antigens expressed by solid tumors in different organs targeted by. CAR-T cells in trials registered at clinicaltrials.gov.

Antigen		Several Organs																			Number of Trials
AFP peptide/A2				√																	2
B7-H3	√	√		√					√				√		√	√		√	√	√	6
CD20													√								1
CD44v6							√			√	√										2
CD70			√			√	√		√				√								2
CD133	√		√	√		√	√	√													3
CD147 (EMMPRIN)	√			√																	2
CD171 (L1CAM)									√												2
CEA		√	√	√	√	√	√	√		√							√				16
claudin 18.2 (CLD18)		√	√							√											6
c-Met/hepatocyte growth factor receptor							√						√								4
DLL3 (delta-like protein 3)					√																1
EGFR	√	√	√	√	√	√		√	√	√					√	√		√	√	√	8
EGFR family member		√																			1
EGFRvIII	√																				11
EGFR806	√																				1
EpCAM			√	√			√	√		√	√	√					√				6
EphA2	√																				2
ErbB2 dimers												√									1
FAP					√																1
FBP (folate binding protein)						√															3
GD2	√	√							√				√			√		√			24
gp100 (209-217/HLA-A2)													√								1
GPC3 (glypican-3)		√		√	√				√						√				√		18
HER2	√	√	√	√	√	√	√	√		√		√		√							17
ICAM1												√									1
IL13Rα2	√												√								6
Lewis Y		√																			2
ligands of chlorotoxin	√																				1
LMP1 (EBV)												√									1
mesothelin		√	√		√	√	√										√				32
MG7				√																	1
MUC1	√	√	√	√	√		√	√		√		√									11
Muc1 (cleaved form)							√														1
MUC16ecto		√				√											√				1
TnMuc1		√	√		√	√	√														1
Nectin4/FAP		√	√		√	√	√							√							1
NKG2D-ligands (MIC-A,-B, ULBP-1,-2,-3,-4,-5,-6)	√	√	√	√		√	√	√		√	√	√		√							6
PD-L1	√				√																5
PSCA		√	√							√	√										4
PSMA	√	√							√		√										11
ROR1		√			√		√														1
ROR2		√	√							√				√	√						2
VEGFR2									√				√								1
Several Ags	√	√	√	√	√	√	√	√	√	√		√	√	√		√					16
undisclosed antigen						√											√				2