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Description of the main known biochemical cascade of events leading to retinopathy of prematurity (ROP). Abbreviations: eNOS, endothelial NO synthase; HIFs, hypoxia-inducible factors; NADPH, dihydronicotinamide-adenine dinucleotide phosphate; NO, nitric oxide; pSTAT3, phosphorylated signal transducer and activator of transcription 3; PGs, prostaglandins; ROP, retinopathy of prematurity; TXA2, thromboxane A2; VEGFR, vascular endothelial growth factor receptor.
