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. 2020 Sep 3;11(9):1039. doi: 10.3390/genes11091039

Table 2.

Association between thyroid cancer history and their family thyroid cancer histories.

Family History ORs of Thyroid Cancer for the Thyroid Cancer Family Histories
Crude p-Value Model 1 p-Value Model 2 p-Value Model 3 p-Value
ORs of the thyroid cancer history of father
Thyroid cancer 7.07 (2.23–22.38) 0.001 1 6.72 (2.10–21.50) 0.001 1 6.75 (2.10–21.67) 0.001 1 6.59 (2.05–21.21) 0.002 1
Control 1.00 1.00 1.00 1.00
ORs of the thyroid cancer history of mother
Thyroid cancer 7.98 (4.47–14.26) <0.001 1 6.33 (3.52–11.36) <0.001 1 5.55 (3.02–10.19) <0.001 1 4.76 (2.59–8.74) <0.001 1
Control 1.00 1.00 1.00 1.00
ORs of the thyroid cancer history of siblings
Thyroid cancer 14.20 (10.40–19.40) <0.001 1 10.16 (7.42–13.93) <0.001 1 13.09 (9.53–17.99) <0.001 1 9.53 (6.92–13.11) <0.001 1
Control 1.00 1.00 1.00 1.00

ORs, odds ratios. Model 1: adjusted for age, sex, income, body mass index, smoking, alcohol intake, and past medical histories of hypertension, diabetes mellitus, and dyslipidemia. Model 2: adjusted for thyroid cancer history of father, mother, and siblings. Model 3: adjusted for Models 1 and 2. 1 Logistic regression analyses, Statistical significance at p < 0.05.