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Interactions between ATP and key residues in different complexes. (A) active AC5 + ATP + Gsα, (B) inactive AC5 + ATP complex, (C) inactive Gαi_tilted + AC5 + ATP complex. Key residues of C2 are shown as sticks and colored in purple (LYS 1065) and green (ARG 1029). The C1 and C2 subunits of AC5 are colored blue and red, respectively. For clarity, the region 394–428 of C1 is omitted from the representation.
