Table 1.
Quantification of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-neutralizing antibodies in sera from convalescent plasma donors (cohort 1).
| Patient No. | Age (y) | Patient Status | Disease Severity | Virus Detection (RT-PCR) | IgG Ratio | IgA Ratio | ND50 a | PVND50 b | ||
|---|---|---|---|---|---|---|---|---|---|---|
| SARS-CoV-2 | SARS-CoV-1 | VSV G | ||||||||
| 1 | 45 | Convalescent | Mild-Moderate | + c | 4.2 | 7.9 | 64 | 20 | <10 | <10 |
| 2 | 64 | + | 4.7 | 5.1 | 92 | 160 | 20 | 160 | ||
| 3 | 64 | + | 3.9 | 5.0 | 65 | 160 | 30 | 160 | ||
| 4 | 53 | + | 1.4 | 0.7 | 28 | 10 | <10 | <10 | ||
| 5 | 53 | + | 1.3 | 1.3 | 40 | 60 | <10 | <10 | ||
| 6 | 42 | + | 2.2 | 2.0 | 56 | 40 | 40 | <10 | ||
| 7 | 49 | + | 2.2 | 4.4 | 65 | 160 | 80 | <10 | ||
| 8 | 49 | + | 3.9 | >8 | 210 | 380 | 50 | 15 | ||
| 9 | 49 | + | 1.7 | >9 | 259 | 640 | 40 | 40 | ||
| 10 | 34 | + | 2.7 | 0.8 | 46 | 20 | <10 | <10 | ||
| 11 | 48 | + | 2.0 | 3.3 | 46 | 20 | <10 | 10 | ||
| 12 | 48 | + | 1.6 | 4.7 | 28 | 25 | <10 | <10 | ||
| 13 | 34 | + | 7.2 | 3.3 | 130 | 80 | <10 | <10 | ||
| 14 | 38 | + | 1.0 | 6.8 | 320 | 400 | 40 | <10 | ||
| 15 | 29 | n.d. d | 1.3 | 7.4 | 56 | 80 | 80 | <10 | ||
| 16 | 27 | + | 3.3 | >8 | 210 | 160 | 160 | <10 | ||
| 17 | 53 | − | 2.4 | 1.3 | <10 | <10 | <10 | <10 | ||
| 18 | 46 | + | 2.3 | 2.7 | 65 | 100 | <10 | <10 | ||
| 19 | 47 | + | 1.3 | 0.1 | 40 | 40 | <10 | <10 | ||
| 20 | 26 | + | 3.3 | 4.2 | 56 | 55 | 10 | <10 | ||
| 21 | 26 | + | 2.7 | 5.6 | 92 | 100 | 80 | <10 | ||
| 22 | 75 | Intensive medical care | Severe | n.d. | 1.9 | >9 | 960 | 640 | 640 | <10 |
| 23 | 66 | + | 11.6 | >8 | 1280 | 1280 | 640 | <10 | ||
| 24 | 56 | n.d. | 13 | >8 | 733 | 480 | 640 | <10 | ||
| 25 | 59 | n.d. | 8.8 | >9 | 450 | 546 | 560 | <10 | ||
a Neutralization dose 50% (ND50); b Pseudotype virus neutralization dose 50% (PVND50); c “+”, detected, “-“, not detected; d n.d., not determined.