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. 2020 Jun 1;29:0963689720927405. doi: 10.1177/0963689720927405

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 3. — LINC00460 targeted and regulated miR-4443 in HNSCC cells. (A) The potential miRNA that could target LINC00460 by the bioinformatics analysis. (B, C) Relative miR-4689, miR-4443, and miR-4665-5p expression in CAL-27 and WSU-HN4 cells following knockdown of LINC00460. (D, E) miR-4443 mimics or mimics NC and GP-miRGLO-LINC00460-WT or GP-miRGLO-LINC00460-MUT were cotransfected into CAL-27 and WSU-HN4 cells. Luciferase activity was detected 24 h after transfection. (F) The predicted binding sites of miR-4443 to the LINC00460 sequence. Data are presented as the mean ± SD, analyzed using Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001. HNSCC: head and neck squamous cell carcinoma; NC: negative control; SD: standard deviation.