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. 2020 Jun 24;29:0963689720934418. doi: 10.1177/0963689720934418

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — miR-26b-5p alters hADMSC adipogenic differentiation. (A) When hADMSCs were transfected with an miR-26b-5p mimic, significant increases in miR-26b-5p expression were observed relative to cells transfected with an miR-Ctrl construct, whereas this expression was significantly reduced in cells transfected with an miR-26b-5p inhibitor relative to corresponding controls. (B) Cells transfected with an miR-26b-5p mimic were evaluated via qPCR, revealing significant increases in the expression of C/EBP, PPARγ, and aP2, and significant decreases in the expression of TCF7L2 and β-catenin relative to cells transfected with the mimic control construct. (C) Cells transfected with an miR-26b-5p inhibitor were evaluated via qPCR, revealing significant increases in the expression of C/EBP, PPARγ, and aP2, and significant decreases in the expression of TCF7L2 and β-catenin relative to cells transfected with the inhibitor control construct. *P < 0.05. GAPDH: glyceraldehyde 3-phosphate dehydrogenase; hADMSC: human adipose-derived mesenchymal stem cell; PPARγ: peroxisome proliferator-activated receptor γ; qPCR: quantitative polymerase chain reaction.