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. 2020 Sep 14;9(9):290. doi: 10.3390/biology9090290

Figure 6.

Figure 6

Possible therapeutic targets to regulate transcription factor function. There are different mechanisms that lead to transcription factor activation (or repression). Regulating these mechanisms can provide possible therapeutic targets. Activating or repressing the binding of cofactors, chromatin remodelers (e.g., UBCS039), and post-translational modifications (e.g., SB303580) or directly influencing the binding of transcription factors to DNA (e.g., MLN944) can be explored as therapeutic options. TF = transcription factors; HDAC = histone deacetylase.