Table 3.

Bleeding complications from direct oral anticoagulant use [10,20,22,23,24,25,26,27,30,31,32,33,34,35,37,38,39,42].

BLEEDING COMPLICATIONS
MAJOR BLEEDING	Intracranial bleeding (subarachnoid hemorrhage, epidural hemorrhage, subdural hemorrhage, and intraparenchymal hemorrhage)
	Intraspinal hemorrhage
	Intraocular hemorrhage (retinal or vitreous hemorrhage)
	Hemorrhagic cardiac tamponade/hemopericardium
	Retroperitoneal hemorrhage
	Gastrointestinal hemorrhage
	Joint hematoma, traumatic or non-traumatic
	Hemoperitoneum, atraumatic splenic rupture
CLINICALLY RELEVANT NON-MAJOR BLEEDING (CRNMB)	Genitourinary–Hematuria, vaginal bleeding, abnormal uterine bleeding
	Respiratory tract–hemoptysis, gingival bleeding, epistaxis
	Intramuscular–Rectus sheath hematoma
	Skin/subcutaneous–Bruising