Figure 3.

TMZ-regulated lncRNAs as novel independent GBM prognosis markers. (a) Overlap between the 360 TMZ-regulated lncRNAs and 133 lncRNAs proposed to correlate with GBM patient prognosis in the TCGA cohort [31]. (b) Kaplan Meier overall survival curves for the four overlapping lncRNAs in gliomas patients. The number of patients (n) analyzed for each group (high lncRNA expression group in red, low lncRNA expression group in blue) is indicated on the graphs. For each group n ≥ 329. Hazard ratios (H.R) and significance (log rank p-value) are indicated on the graphs. (c) Box plots of selected lncRNA median expression in GBM (n = 163) and lower grade gliomas (LGG, n = 518) (in red) compared to control brain tissue (grey, n = 207). Significant expression change is indicated by a red asterisk.