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. 2020 Sep 10;12(9):2583. doi: 10.3390/cancers12092583

Figure 5.

Figure 5

Identification of TMZ-associated transcriptional regulatory motifs involving lncRNAs. (a) Graphical representation of the motif structures where mRNAs or lncRNAs are the targets regulated by miRNA (miR) and TF associations. (b) Hive plot representing TMZ-regulated FFLs containing lncRNAs from NCH601. Axes indicate different RNA families, with each dot corresponding to a gene (TF, miRNA, or lncRNA) involved in lncRNA-containing loops. Molecular interactions are represented by a color code line (stimulatory interactions in red, inhibitory interactions in blue). (c) Heatmap showing enriched pathway for the indicated lncRNAs.