ICIs:	Immune checkpoint inhibitors;
NSCLC:	Non-small cell lung cancer;
EGFR:	Epidermal growth factor receptor;
PD-L1:	programmed death-ligand 1;
DMRs:	differentially methylated regions;
PLCXD3:	Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 3;
BAIAP2L2:	BAR/IMD Domain Containing Adaptor Protein 2 Like 2;
NPR3:	Natriuretic Peptide Receptor 3;
SNX10:	Sorting Nexin 10;
XDH:	Xanthine Dehydrogenase;
ATIC:	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase;
CA9:	Carbonic Anhydrase 9;
SLC7A11:	Solute Carrier Family 7 Member 11;
GAPDH:	Glyceraldehyde-3-Phosphate Dehydrogenase;
TKI:	Tyrosine kinase inhibitors;
PD1:	Programmed death 1;
ALK:	ALK receptor tyrosine kinase;
OS:	Overall survival;
IDO:	Indoleamine 2,3-dioxygenase;
VEGF:	Vascular endothelial growth factor;
CTLA-4:	Cytotoxic T-lymphocyte-associated protein 4;
LAG-3:	Lymphocyte-activation gene 3;
Tim-3:	T-cell immunoglobulin mucin 3;
TCGA:	The Cancer Genome Atlas;
DMEGs:	differentially methylated and expressed genes;
GEO:	Gene Expression Omnibus;
DMSs:	Differentially methylated CpG sites;
DMRs:	Differentially methylated regions;
DMGs:	Differentially methylated genes;
FDR:	False discovery rate;
BH:	Benjamini and Hochberg;
DEGs:	Differentially expressed genes;
GO:	Gene Ontology;
KEGG:	Kyoto Encyclopedia of Genes and Genomes;
BP:	Biological process;
CC:	Cellular component;
MF:	Molecular functions;
PCA:	Principal Component Analysis;
LOOCV:	Leave-one-out cross-validation;
ROC:	Receiver operating characteristic;
AUC:	Area under the curve;
LASSO:	Least Absolute Shrinkage and Selection Operator;
TIMER:	Tumor immune estimation resource;
ESTIMATE:	Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data;
RMSD:	Root-mean-square deviation;
TSS	Transcription start sites
CD274:	CD274 molecule, also known as PD-L1;
HAVCR2:	Hepatitis A Virus Cellular Receptor 2, also known as TIM3;
PDCD1:	Programmed Cell Death 1, also known as PD1;
PDCD1LG2:	Programmed Cell Death 1 Ligand 2;
CDO1:	Cysteine Dioxygenase Type 1;
IRF8:	Interferon Regulatory Factor 8;
STAT5A:	Signal Transducer and Activator of Transcription 5A;
CFTR:	CF Transmembrane Conductance Regulator;
ADAMTS8:	ADAM Metallopeptidase with Thrombospondin Type 1 Motif 8;
WIF1:	WNT Inhibitory Factor 1;
GATA5:	GATA Binding Protein 5;
FOXA2:	FOXA2;
SHISA3:	Shisa Family Member 3;
AXIN2:	Axin 2;
DIRAS3:	DIRAS family GTPase 3;
IRX1:	Iroquois Homeobox 1;
ITGA5:	Integrin Subunit Alpha 5;
CAMK2N1:	Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1;
CRC:	Colorectal cancer;
SNX10:	Sorting nexin 10;
ALS:	Amyotrophic lateral sclerosis;
IBD:	Inflammatory bowel disease