Table 1.
Correlation of clinicopathological parameters of breast cancer patients with selected markers of mTOR complexes (determined by IHC). * p < 0.05.
| p-S6 Expression | Rictor Expression | |||||||
|---|---|---|---|---|---|---|---|---|
| “Low” | “High” | 95% CI | p Value | “Low” | “High” | 95% CI | p Value | |
| Age (years) | ||||||||
| ≤55 (n = 41) | 25 (61) | 16 (39) | 105.26–150.84 | 0.021 * | 17 (46) | 20 (54) | 157.00–196.51 | 0.666 |
| >55 (n = 54) | 18 (36) | 32 (64) | 147.23–186.97 | 27 (53) | 24 (47) | 153.35–188.61 | ||
| Subtype | ||||||||
| n = 43 | n = 48 | 0.733 | n = 44 | n = 44 | 0.613 | |||
| Luminal A (n = 16) |
7 (47) | 8 (53) | 103.10–196.90 | 6 (40) | 9 (60) | 167.88–213.45 | ||
| Luminal B1 (n = 19) |
10 (56) | 8 (44) | 103.85–167.81 | 9 (47) | 10 (53) | 142.67–205.75 | ||
| Luminal B2 (n = 22) |
12 (55) | 10 (45) | 106.69–172.40 | 10 (56) | 8 (44) | 154.70–204.19 | ||
| HER2+ (n = 19) |
7 (37) | 12 (63) | 135.85–207.47 | 7 (41) | 10 (59) | 135.10–211.96 | ||
| TNBC (n = 19) |
7 (41) | 10 (59) | 111.64–188.36 | 12 (63) | 7 (37) | 121.35–184.97 | ||
| Grade | 0.256 | 0.441 | ||||||
| 1 (n = 7) | 3 (43) | 4 (57) | 78.66–218.48 | 4 (67) | 2 (33) | 125.89–224.11 | ||
| 2 (n = 38) | 13 (37) | 22 (63) | 140.59–188.55 | 15 (43) | 20 (57) | 168.06–205.09 | ||
| 3 (n = 50) | 27 (55) | 22 (45) | 117.37–160.38 | 25 (53) | 22 (47) | 143.90–182.91 | ||
| pT Stage | 0.146 | 0.636 | ||||||
| 1 (n = 44) | 25 (58) | 18 (42) | 122.80–165.80 | 17 (43) | 23 (57) | 163.11–199.89 | ||
| 2 (n = 40) | 15 (39) | 23 (61) | 128.96–180.52 | 21 (57) | 16 (43) | 147.20–187.93 | ||
| 3 (n = 5) | 2 (50) | 2 (50) | 13.11–216.89 | 3 (60) | 2 (40) | 91.72–220.28 | ||
| 4 (n = 6) | 1 (17) | 5 (83) | 100.80–252.54 | 3 (60) | 2 (40) | 71.33–268.67 | ||
| pN Stage | 0.596 | 0.829 | ||||||
| x (n = 1) | 0 (0) | 1 (100) | not applicable | 1 (100) | 0 (0) | not applicable | ||
| 0 (n = 42) | 20 (50) | 20 (50) | 121.27–169.23 | 17 (45) | 21 (55) | 158.09–199.28 | ||
| 1 (n = 38) | 16 (44) | 20 (56) | 135.20–182.03 | 20 (56) | 16 (44) | 150.11–191.56 | ||
| 2 (n = 12) | 7 (58) | 5 (42) | 70.88–164.95 | 5 (45) | 6 (55) | 132.30–231.16 | ||
| 3 (n = 2) | 0 (0) | 2 (100) | 0.00–300.00 | 1 (50) | 1 (50) | 0.00–300.00 | ||
| Metastasis (n = 38) |
8 (23) | 27 (77) | 141.92–189.23 | 0.0003 * | 21 (58) | 15 (42) | 144.52–186.59 | 0.278 |
| W/O Metastasis (n = 57) | 35 (63) | 21 (37) | 119.47–159.46 | 23 (44) | 29 (56) | 162.10–195.59 | ||
pT: pathologic T stage (tumour size); pN: pathologic N stage (lymph node metastases); W/O: without.