Table 3.
Correlation of clinicopathological parameters of breast cancer patients with CPT1A and FASN expression (determined by IHC). p < 0.05.
| CPT1A Expression | FASN Expression | |||||||
|---|---|---|---|---|---|---|---|---|
| “Low” | “High” | 95% CI | p Value | “Low” | “High” | 95% CI | p Value | |
| Age (years) | ||||||||
| ≤55 (n = 41) | 18 (51) | 17 (49) | 212.97–249.60 | 0.657 | 11 (30) | 26 (70) | 185.67–224.06 | 0.814 |
| >55 (n = 54) | 27 (57) | 20 (43) | 207.78–239.46 | 15 (33) | 30 (67) | 197.95–234.05 | ||
| Subtype | ||||||||
| n = 45 | n = 37 | 0.454 | n = 26 | n = 56 | 0.208 | |||
| Luminal A (n = 16) |
6 (40) | 9 (60) | 238.20–271.13 | 3 (20) | 12 (80) | 216.35–267.65 | ||
| Luminal B1 (n = 19) |
9 (50) | 9 (50) | 208.35–252.76 | 5 (31) | 11 (69) | 162.74–243.51 | ||
| Luminal B2 (n = 22) |
9 (53) | 8 (47) | 202.80–247.79 | 6 (30) | 14 (70) | 195.61–243.39 | ||
| HER2+ (n = 19) |
11 (73) | 4 (27) | 162.57–240.76 | 3 (20) | 12 (80) | 198.33–248.33 | ||
| TNBC (n = 19) |
10 (59) | 7 (41) | 190.01–254.69 | 9 (56) | 7 (44) | 141.00–194.00 | ||
| Grade | 1.000 | 0.119 | ||||||
| 1 (n = 7) | 3 (50) | 3 (50) | 193.81–292.85 | 0 (0) | 6 (100) | 220.25–263.09 | ||
| 2 (n = 38) | 19 (56) | 15 (44) | 214.55–244.87 | 14 (41) | 20 (59) | 179.16–230.25 | ||
| 3 (n = 50) | 23 (55) | 19 (45) | 203.07–241.45 | 12 (29) | 30 (71) | 196.68–226.65 | ||
| pT Stage | 0.625 | 0.154 | ||||||
| 1 (n = 44) | 19 (53) | 17 (47) | 215.93–249.90 | 8 (21) | 31 (79) | 202.23–239.82 | ||
| 2 (n = 40) | 20 (56) | 16 (44) | 210.03–244.41 | 14 (41) | 20 (59) | 180.26–222.09 | ||
| 3 (n = 5) | 2 (40) | 3 (60) | 107.99–300.00 | 2 (40) | 3 (60) | 150.92–273.08 | ||
| 4 (n = 6) | 4 (80) | 1 (20) | 129.45–238.55 | 2 (50) | 2 (50) | 76.99–300.00 | ||
| pN Stage | 0.145 | 0.186 | ||||||
| x (n = 1) | 0 (0) | 1 (100) | not applicable | 0 (0) | 1 (100) | not applicable | ||
| 0 (n = 42) | 24 (67) | 12 (33) | 205.83–238.34 | 13 (34) | 25 (66) | 181.63–223.11 | ||
| 1 (n = 38) | 16 (48) | 17 (52) | 210.70–249.30 | 8 (24) | 26 (76) | 197.75–238.14 | ||
| 2 (n = 12) | 5 (50) | 5 (50) | 168.28–273.72 | 3 (43) | 4 (57) | 179.18–257.96 | ||
| 3 (n = 2) | 0 (0) | 2 (100) | 142.94–300.00 | 2 (100) | 0 (0) | not applicable | ||
| Metastasis (n = 38) |
16 (50) | 16 (50) | 198.99–243.51 | 0.503 | 12 (38) | 20 (62) | 172.64–220.49 | 0.467 |
| W/O Metastasis (n = 57) |
29 (58) | 21 (42) | 216.92–244.08 | 14 (28) | 36 (72) | 205.38–235.02 | ||
pT: pathologic T stage (tumour size); pN: pathologic N stage (lymph node metastases); W/O: without.