Table 2.
Laboratory findings of patients stratified by three levels of serum sodium
| Attribute, median (IQR) | Total (n = 1254) | Serum bloood sodium | p value | ||||
|---|---|---|---|---|---|---|---|
| Hyponatremia (n = 124) (<135 mmol/L) | Normonatremia (n = 1100) (135-145 mmol/L) | Hypernatremia (n = 30) (>145 mmol/L) | p1 (1-2) | p2 (2-3) | p3 (1-3) | ||
| Blood tests, median (IQR) | |||||||
| Leukocytes count ×106/L | 5410 (3000) | 5815 (3340) | 5400 (2820) | 5410 (5370) | 0.031* | 0.259 | |
| Neutrophils count ×106/L | 3580 (2620) | 4560 (3400) | 3460 (2490) | 4290(4180) | <0.001* | 1.000 | 0.177 |
| Lymphocyte count ×106/L | 1110 (790) | 705 (450) | 1180 (810) | 970 (650) | <0.001* | 0.250 | 0.062 |
| Eosinophils count ×106/L | 30 (90) | 10 (30) | 30 (90) | 15 (80) | <0.001* | 0.144 | 1.000 |
| Erythrocyte×106/L | 4290 (710) | 4190 (840) | 4310 (700) | 4155 (770) | |||
| Hemoglobin, g/L | 130 (22) | 127 (25) | 130 (22) | 124 (23.75) | |||
| Platelet ×109/L | 195 (100.5) | 172 (98.5) | 196 (102) | 220 (90) | 0.021* | 0.740 | 0.062 |
| Laboratory tests, median (IQR) | |||||||
| HS-CRP, mg/L, | 12.1 (46.3) | 62 (87.875) | 9.1 (36.72) | 53 (89.6) | <0.001* | 0.002* | 0.598 |
| Procalcitonin, ng/ml, | 0.05 (0.1) | 0.11 (0.17) | 0.045 (0.078) | 0.069 (0.166) | <0.001* | 0.580 | 0.205 |
| Fibrinogen, g/L | 3.61 (2.02) | 4.47 (1.89) | 3.45 (2.01) | 4.77 (2.19) | <0.001* | 0.002* | 1.000 |
| D-Dimer, ug/L | 0.490 (0.890) | 0.955 (2.21) | 0.450 (0.770) | 1.560 (3.72) | <0.001* | <0.001* | 0.333 |
| FDP, ug/L | 3.330 (3.500) | 5.31 (5.44) | 3.09 (3.17) | 6.95 (9.94) | <0.001* | <0.001* | 0.601 |
| Total bilirubin, mmol/L | 10.90 (6.50) | 11.32 (7.40) | 10.98 (6.33) | 8.10 (9.90) | 0.648 | 0.107 | 0.039* |
| Direct bilirubin, mmol/L | 3.70 (2.20) | 4.30 (2.60) | 3.60 (2.10) | 3.00 (4.25) | 0.001* | 1.000 | 0.095 |
| ALT, U/L | 23.00 (24.05) | 27.00 (30.45) | 22.00 (23.40) | 25.00 (34.25) | 0.032* | 0.320 | 1.000 |
| GOT, U/L | 28.90 (18.50) | 39.00 (25.30) | 28.00 (17.42) | 31.00 (31.50) | <0.001* | 1.000 | 0.104 |
| Total protein, g/L | 68.05 (9.20) | 66.00 (8.20) | 68.30 (9.23) | 67.90 (8.70) | 0.001* | 1.000 | 0.898 |
| Albumin, g/L | 38.2 (7.80) | 35.50 (6.30) | 38.50 (7.70) | 33.40 (7.05) | <0.001* | <0.001* | 0.297 |
| Prealbumin, mg/L | 164.00 (141.38) | 95.00 (62.00) | 179.50 (137.80) | 107.50 (101.75) | <0.001* | 0.005* | 0.484 |
| Globulin, g/L | 30.0 (7.30) | 30.90 (7.35) | 29.90 (7.38) | 33.70 (7.55) | 1.000 | 0.001* | 0.010* |
| Glutamyltranspeptidase, U/L | 27.00 (28.00) | 34.00 (43.70) | 26.00 (27.95) | 26.00 (20.50) | 0.012* | 1.000 | 0.276 |
| Alkaline phosphatase, U/L | 59.00 (28.00) | 60.00(34.00) | 59.00 (28.00) | 52.00 (28.00) | 0.401 | 0.031* | 0.023* |
| Urea nitrogen, umol/L | 4.10 (2.30) | 4.88 (2.95) | 4.08 (2.10) | 5.90 (7.00) | 0.002* | 0.007* | 0.780 |
| Creatinine, umol/L | 64.00 (25.00) | 69.00 (26.60) | 63.05 (25.00) | 68.00 (36.50) | 0.002* | 0.151 | 1.000 |
| Uric acid, umol/L | 261.00 (135.00) | 253.00 (137.25) | 261.00 (133.50) | 275.00 (193.00) | 0.361 | 0.772 | 0.893 |
| Total cholesterol, umol/L | 3.99 (1.30) | 3.61 (1.01) | 4.04 (1.40) | 3.70 (1.58) | <0.001* | 0.241 | 1.000 |
| Triglyceride, umol/L | 1.21 (0.81) | 1.17 (0.64) | 1.22 (0.85) | 1.425 (1.13) | 0.528 | 0.052 | 0.033* |
| HDL, umol/L | 1.01 (0.39) | 0.95 (0.42) | 1.02 (0.40) | 0.875 (0.36) | 0.032* | 0.153 | 1.000 |
| LDL, umol/L | 2.48 (1.12) | 2.15 (0.94) | 2.50 (1.13) | 2.50 (1.27) | 0.001* | 1.000 | 0.761 |
| Homocysteine, umol/L | 7.70 (3.50) | 8.20 (5.45) | 7.70 (3.45) | 7.20 (5.48) | 0.108 | 0.364 | 0.091 |
| CK, U/L | 67.00 (68.5) | 92.00 (110.00) | 64.00 (65.00) | 71.50 (126.50) | <0.001* | 0.692 | 0.553 |
| CK-MB, U/L | 9.22 (6.55) | 11.00 (10.42) | 9.10 (5.63) | 8.55 (17.10) | 0.016* | 1.000 | 0.937 |
| Hs-cTnI, ng/ml | 0.01 (0.00) | 0.01 (0.00) | 0.01 (0.00) | 0.01 (0.01) | 0.664 | ||
| LDH, U/L | 206.50 (11.75) | 287.55 (169.00) | 200.00 (99.00) | 278.50 (206.25) | <0.001* | 0.001* | 1.000 |
| Potassium, mmol/L | 3.90 (0.62) | 3.755 (0.73) | 3.90 (0.64) | 3.65 (0.65) | 0.004* | 0.019* | 0.946 |
| Chlorine, mmol/L | 104.05 (5.47) | 99.00 (5.50) | 104.90 (5.00) | 109.70 (5.65) | <0.001* | <0.001* | <0.001* |
| Total calcium, mmol/L | 2.11 (0.21) | 2.03 (0.17) | 2.12 (0.20) | 2.00 (0.19) | <0.001* | 0.001* | 1.000 |
*Significant statistical difference
HS-CRP High sensitivity C-reactive protein, FDP Fibrinogen degradation products, ALT Alanine aminotransferase, GOT Glutamic oxaloacetate, HDL High-density lipoprotein, LDL Low-density lipoprotein, CK Creatine kinase, CK-MB Creatine phosphokinase MB, Hs-cTnI High sensitivity troponin, LDH Lactate dehydrogenase