Fig. 6.

Resveratrol inhibits VEGF-A, SDF-1, and IL-6 expression and mitigates the desmoplastic reaction in KPC mice. (A) Representative images of Masson’s trichrome staining and immunohistochemical staining for VEGF-A, SDF-1, IL-6, α-SMA, and HIF-1α in the vehicle control and resveratrol intervention groups. Scale bars = 50 μm. (B) Resveratrol inhibited α-SMA and HIF-1 expression in KPC mice with pancreatic cancer was detected by western blot. #P < 0.05; ##P < 0.01 vs the untreated group. HIF-1: hypoxia-inducible factor 1; IL-6: interleukin 6; SDF-1: stromal cell-derived factor 1; α-SMA: alpha-smooth muscle actin; VEGF-A: vascular endothelial growth factor A.