Table 1.
Combination Index of ONC206 in combination with paclitaxel in uterine serous cancer cells.
| ONC206 (μM) | Paclitaxel (nM) | Combination Index | ||
|---|---|---|---|---|
| ARK1 | ARK2 | HEC50 | ||
| 0.3125 | 0.5 | 1.180 | 0.179 | 0.613 |
| 1 | 0.889 | 0.267 | 0.527 | |
| 5 | 0.431 | 0.658 | 0.496 | |
| 10 | 0.488 | 0.480 | 0.582 | |
| 0.625 | 0.5 | 0.464 | 0.224 | 1.702 |
| 1 | 0.389 | 0.379 | 1.292 | |
| 5 | 0.484 | 0.164 | 0.619 | |
| 10 | 0.554 | 0.204 | 0.919 | |
| 2.5 | 0.5 | 0.321 | 0.441 | 2.637 |
| 1 | 0.335 | 0.301 | 0.592 | |
| 5 | 0.392 | 0.432 | 0.371 | |
| 10 | 0.463 | 0.177 | 0.627 | |
| 10 | 0.5 | 0.347 | 0.111 | 0.801 |
| 1 | 0.225 | 0.184 | 0.559 | |
| 5 | 0.281 | 0.117 | 0.304 | |
| 10 | 0.345 | 0.398 | 0.284 | |