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. 2020 Sep 7;12(9):2540. doi: 10.3390/cancers12092540

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transmission electron micrographs of gastrocnemius muscles from control mice (A,B) and mice treated for 14 days with bortezomib (C–E). Note the large-sized subsarcolemmal (sm) and intermyofibrillar (im) mitochondria in C and E compared to the mitochondria in A and B, and the sarcoplasmic enlargements in D (asterisks). Nucleus (n). Bars: 500 nm. (F) Histograms in F show the mean ± SE values of sectional area and inner/outer membrane ratio of subsarcolemmal and intermyofibrillar mitochondria in gastrocnemius muscles from control mice and mice treated for 7 or 14 days with bortezomib. All values are significantly different from each other.