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Optimization of complexation factors in preparation of Fu/PG5.
| Complexation | pH | Time (h) | Molar ratio (Fu to PG5) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Factors | 5.0 | 7.4 | 9.0 | 2 | 4 | 6 | 20 | 100 | 200 |
| EE (%) | 14.8 ± 1.2 | 17.8 ± 0.8 | 8.8 ± 1.2 | 12.3 ± 0.4 | 26.4 ± 0.3 | 27.8 ± 0.2 | 46.8 ± 0.2 | 25.8 ± 0.3 | 17.6 ± 0.4 |
| DLC (%) | 7.2 ± 0.4 | 9.1 ± 0.2 | 4.5 ± 0.1 | 4.9 ± 0.1 | 10.1 ± 0.5 | 11.6 ± 0.4 | 3.7 ± 0.1 | 9.8 ± 0.3 | 10.2 ± 0.3 |
Data are mean ± SD, n = 3. EE, encapsulation efficiency; DLC, drug loading capacity.
