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(A) PROTACs dose-dependently downregulates α1A-AR levels. α1A-AR stably transfected HEK293 cells were incubated with PROTACs at indicated concentrations for 12 h. (B) Cells were incubated with 3 μmol/L PROTACs for the indicated time. (C) Quantitative analysis of the Western blot in Fig. 1A. (D) Quantitative analysis of the Western blot in Fig. 1B.
