Figure 1.

Dual antigen chimeric antigen receptor CAR T approaches. (a) Coadministration: involves production of two separate CAR T cell products infused together or sequentially. (b) Bicistronic: allows expression of two different CARs on the same cell. (c) Cotransduction: encodes two CAR constructs with multiple vectors. With this process, one will also obtain cells that express each CAR alone. (d) Tandem: encodes two CARs on same chimeric protein using a single vector. This work is licensed under a CC-BY Creative Commons attribution license, version 4.0 [32].