Figure 2.

Concentration–time profiles of ginsenosides in plasma after single or multiple administration of SMI to Balb/c nude mice harboring LoVo xenografts. (A) and (B) Mice were intraperitoneally injected with SMI (10 mL/kg/day) once a day for one day (A) or for eight days (B). Ginsenosides in plasma were detected at 5, 10, 20 40 min, 1, 2, 4, 8, 12, 24, 48 and 96 h after the last SMI administration (n = 5 mice at each time point). (C) AUC_0–∞ of ginsenosides in plasma after single or multiple SMI injection. The ratio between multiple and single administration was calculated to evaluate the accumulation of different ginsenosides in plasma after multiple SMI administration. Data were expressed as mean ± SEM. AUC: area under curve.