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. 2019 Dec 18;10(9):1694–1708. doi: 10.1016/j.apsb.2019.12.011

Figure 8.

Figure 8

Influence of Rd on the anti-tumor effect of chemotherapy in vivo. Schematic plans of animal experiments. Mice were intraperitoneally injected with SMI (10 mL/kg/day), Rd (5 mg/kg/day) or 5FU (15 mg/kg/3 days) for 20 days. (B) and (C) SMI and Rd enhance the inhibition effect of 5FU on tumor growth. (B) Images of tumors resected from mice after 20-day treatment. (C) Tumor volumes after 20-day treatment. (D) Changes in mice body weight after 17-day treatment. (E) Concentration of 5FU in tumor tissues after 20-day treatment. Data were expressed as mean ± SEM. *P < 0.05, **P < 0.01 vs. vehicle + saline group, #P < 0.05, ##P < 0.01 vs. vehicle+5FU group, n = 6–7.