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Total DNA content per cardiomyocyte in relation to their proliferative capacity. Newt and zebrafish cardiomyocytes stay mononucleated, diploid, and proliferative their whole life. Newborn mouse and human cardiomyocytes have similar characteristics as newt and zebrafish, but the mouse cardiomyocytes become binucleated and human cardiomyocytes become tetraploid when they become adults. Simultaneously, these cardiomyocytes lose the ability to proliferate.
