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. 2020 Sep 22;12(9):2715. doi: 10.3390/cancers12092715

Figure 4.

Figure 4

Bioenergetic dynamics are regulated by menin and MAPs in T47D and MCF-7 cells. (A) and (B) Glycolytic and OXPHOS ATP productions in T47D (A) or MCF-7 (B) cells infected with vehicle, shMEN1, shKMT2A, shMED12, shWAPL, or shGATA3 lentivirus. Statistics represented the difference of glycolytic or OXPHOS ATP production between shRNA knockdown and vehicle controls. (C) and (D) Bar charts representing mitochondrial functions in the single knockdown of MEN1, KMT2A, MED12, WAPL, or GATA3 and their vehicle control in T47D (C) or MCF-7 (D) cells. (E) Schematic summary of mitochondrial dynamics affected by the knockdown of MEN1 or MAPs. (F,G) Bar charts represented the glycolytic functions in T47D (F) or MCF-7 (G) cells subject to gene knockdown by shMEN1, shKMT2A, shMED12, shWAPL, or shGATA3 lentivirus. (H) Schematic summary of glycolytic functions affected by the knockdown of MEN1 or MAPs. Data are presented as mean ± S.D. (n = 15–20 technical-replicate wells). Statistical significance was performed by an unpaired two-tailed Student’s t-test between treated groups and corresponding controls. * p < 0.05, ** p < 0.01, and *** p < 0.001.