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. 2020 Jun 28;26(11):1111–1120. doi: 10.1111/cns.13434

FIGURE 3.

FIGURE 3

Pharmaco‐genetic inhibiting pyramidal neurons efficiently alleviate the severity of kindling‐induced seizures. A, B, Representative EEGs (A) and statistics of afterdischarge duration (ADD) (B) recorded from the hippocampus at the 30th stimulation during epileptogenesis from PV‐hM3Dq mice. n = 8 for each group, unpaired t test was used. C, D, Representative EEGs (C) and statistics of ADD (D) recorded from the hippocampus at the 30th stimulation during epileptogenesis from CaMKIIa‐hM4Di mice. n = 8 for each group, *P < .05, compared with Saline group, unpaired t test was used. E, F, The effects of pharmaco‐genetic activating parvalbumin neurons on the EEG spectrum analysis (E) and statistics of each EEG rhythm (F) during hippocampal seizures in PV‐hM3Dq mice. n = 8 for each group, *P < .05, compared with Saline group, unpaired t test was used. G, H, The effects of pharmaco‐genetic activating parvalbumin neurons on the EEG spectrum analysis (G) and statistics of each EEG rhythm (H) during hippocampal seizures in CaMKIIa‐hM4Di mice. n = 8 for each group, *P < .05, **P < .01, ***P < .001, compared with Saline group, unpaired t test was used. Data are presented as means ± SEM