FIGURE 3.

Effect of TEFTS on glioma growth in rats. A, Body weight. B, Survival curve. C, Tumor growth over time was monitored by MRI. Representative MRI images of TEFTS‐treated rats and non‐treated control rats from 1st to 8th weeks after tumor transplantation (a). Continuous TEFTS treatment significantly reduced tumor volume at 2nd and 3rd week after tumor inoculation (b‐d). Changes of tumor volume over time in individual rat were displayed in (e). D, Continuous TEFTS treatment for 8 wk. In the first 4 wk, the tumor volume gradually increased. The tumor volume was significantly reduced from the 5th week to the 8th week. After stopping the treatment, no rebound was observed at the 10th and 12th week. The white arrows show the tumor, orange arrows indicate the area after the tumor shrinks/disappears. *P < .05；** P < .01; ***P < .001; ****P < 0001