Figure 1.

Pedigrees of families meeting criteria for establishing an association between MS and variants of genes encoding TNF receptors. A, Family with presence of variants rs20575 and rs17620 in homozygosis in individuals with MS. B, Family with presence of variant rs35041805 in individuals with MS. C, Family with presence of variant rs35041805 in individuals with MS and individuals with another AID. D, Family with presence of variant rs9550987 in individuals with MS. Arrow: proband; asterisk: whole‐exome sequencing; black: MS; gray: AID