Table 1.
Demographic and clinical characteristics of the cohort classified in cases with MS, cases with AID, and unaffected individuals
|
MS N = 43 (37.1%) |
AID N = 16 (13.8%) |
Unaffected individuals N = 57 (49.1%) |
|
|---|---|---|---|
| Age | 46.0 ± 10.5 | 58.6 ± 11.4 | 54.2 ± 19.0 |
| Sex | Women: 25 (58.1%) | Women: 14 (87.5%) | Women: 34 (59.6%) |
| Men: 18 (41.9%) | Men: 2 (12.5%) | Men: 23 (40.4%) | |
| Clinical form of MS | RRMS: 34 (79.1%) | NA | NA |
| SPMS: 5 (11.6%) | |||
| PPMS: 4 (9.3%) | |||
| Progression time of MS (months) | 218.3 ± 110.0 | NA | NA |
| Other AIDs | 9 (20.9%) (rheumatic fever, DM‐1, hypothyroidism, ulcerative colitis, uveitis, systemic lupus erythematosus, Guillain‐Barré syndrome) | Hypothyroidism, DM‐1, rheumatoid arthritis, uveitis, systemic lupus erythematosus, hyperthyroidism, and psoriasis | NA |
| Type of familya | Type A: 23 (53.5%) | Type A: 10 (62.5%) | Type A: 33 (57.9%) |
| Type B: 20 (46.5%) | Type B: 6 (37.5%) | Type B: 24 (42.1%) |
Abbreviations :AID, autoimmune disease; DM‐1, type I diabetes mellitus; MS, multiple sclerosis; NA, not applicable; RRMS, relapsing‐remitting MS; SPMS, secondary‐progressive MS; PPMS, primary‐progressive MS.
a
Type A: all patients with MS belong to the same generation. Type B: more than one generation is affected by MS.