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. 2020 Sep 14;12(9):2623. doi: 10.3390/cancers12092623

Figure 1.

Figure 1

Modular domain (a) and crystal (b) structures of the peroxisome proliferator-activated receptor gamma (PPARγ). Ligand-binding activity of the PPARγ and retinoid X receptors (RXR) heterodimer, which is bound in the cytosol to the nuclear receptor corepressor complexes (N-CoR) or silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), while in the nucleus is activated by PPARγ coactivator 1-α (PGC-1α) or binding protein p300 (EP300) for binding to the PPRE in the promoter of target genes (c).