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. 2020 Sep 14;12(9):2623. doi: 10.3390/cancers12092623

Figure 3.

Figure 3

Activation of PPARγ induces autophagy in breast cancer cells. Natural and synthetic PPARγ increase hypoxia-inducible factor 1 (HIF1α) and Beclin-1 expression, which also results from the dissociation of the Beclin-1/Bcl2 complex thereby inducing autophagy.