Figure 2.

Schematic representation of pathways implicated in K⁺ regulation in pulmonary artery smooth muscle cells in the context of pulmonary arterial hypertension (PAH). [Ca²⁺]_cyt, cytoplasmic calcium concentration; [K⁺]_cyt, cytoplasmic potassium concentration; 5-HTR, serotonin receptor; AT1-R, angiotensin 1 receptor; BMPRI, BMP receptor type I; BMPRII, BMP receptor type II; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; DAG, diacylglycerol; Em, membrane resting potential; ET-R, endothelin receptor; IP3, inositol-1,4,5-triphosphate; MAPK, mitogen-activated protein kinases; PIP2, phosphatidylinositol-4,5-biphosphate; PKA, protein kinase A; PKC, protein kinase C; PKG, protein kinase G; PLC, phospholipase C; SMAD, mothers against decapentaplegic homologue; SrcTK, Src family tyrosine kinase; TXA2R, thromboxan A2 receptor.