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. 2020 Sep 1;10(9):1261. doi: 10.3390/biom10091261

Figure 4.

Figure 4

General molecular architecture of ATP-sensitive potassium channels (KATP) channels. The KATP form in a hetero-octameric conformation is composed of four inward-rectifier-K+ channel subunits (Kir6.x), which represent the pore forming subunits, and four regulatory subunits (Sur.x, sulfonylurea receptor). There are two types of Kir 6.x subunits (Kir6.1 and Kir6.2) and two types of Sur.x subunits (SUR1 and SUR2), and there are two splice variants of SUR2 (SUR2A and SUR2B). KATP subunits co-assemble in different manners, depending on the tissue type. TMD: Transmembrane domain. NBD: Nucleotide binding domain.