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General molecular architecture of voltage-gated K+ channels (Kv channels). Kv channels are comprised of a voltage sensor domain (VSD), which detects changes in the transmembrane voltage, and a pore domain (PD). The VSD and PD are comprised of six transmembrane domains. Kv channels are also comprised of a β subunit. Kv channels form as homo- or heterotetramers composed of four α subunits and four β subunits.
