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. 2020 Aug 27;12(9):2438. doi: 10.3390/cancers12092438

Figure 3.

Figure 3

Interaction of the Hippo pathway and phosphatases in tumorigenesis. PSPs (PP2A/PR55α, PP1, PP1A, POPX2, and MYPT1; gene symbols with orange background) and PTPs (SHP2/PTPN1, PTPN14, PTPN21, CDC14, PTEN; gene symbols with yellow background) can regulate tumorigenesis through positive or negative regulation of the Hippo pathway (gene symbols with purple background). Dotted blue lines includes core components of the Hippo pathway (MST1/2, MAP4Ks, SAV1, MOB1, LATS1/2, and YAP/TAZ). In addition, the Hippo pathway can directly or indirectly regulate several phosphatases (PP2A, CDC25, and PTEN; dotted orange lines).