Table 1.
Patient characteristics and immunohistochemical staining characteristics.
| Variables | ADC | SqCC |
|---|---|---|
| Overall, n | 499 | 440 |
| Sex, n (%) | ||
| male | 291 (58) | 368 (84) |
| female | 208 (42) | 72 (16) |
| Age, median (min–max) | 63 (30–89) | 65 (38–83) |
| TNM, n (%) | ||
| pT1 | 93 (19) | 85 (19) |
| pT2 | 321 (64) | 259 (59) |
| pT3 | 70 (14) | 78 (18) |
| pT4 | 15 (3) | 18 (4) |
| pN0 | 252 (51) | 207 (47) |
| pN1 | 70 (14) | 148 (34) |
| pN2 | 155 (31) | 78 (18) |
| pN3 | 4 (1) | 0 (0) |
| pNX | 18 (3) | 7 (2) |
| pM1 | 24 (5) | 5 (1) |
| pMX | 475 (95) | 435 (99) |
| Stage, n (%) | ||
| I | 201 (40) | 149 (34) |
| II | 101 (20) | 171 (39) |
| III | 173 (35) | 115 (26) |
| IV | 24 (5) | 5 (1) |
| Immunohistochemistry | ||
| CK5/6 | 10 (2) | 412 (94) |
| CK7 | 474 * (97) | 91 # (21) |
| Napsin-A | 369 (74) | 5 (1) |
| p40 | 19 (4) | 414 (94) |
| TTF-1 | 433 (87) | 3 (1) |
* n = 8, not available; # n = 11, not available. Abbreviations: ADC, adenocarcinoma; CK, cytokeratin; TNM, size/direct extent of the primary tumor, degree of spread to regional lymph nodes (pN0 = no lymph node metastases, pN1 = lymph node metastases to ipsilateral peribronchial and or hilar or intrapulmonal lymph nodes, pN2 = lymph node metastases to ipsilateral mediastinal and or subcarinal lymph nodes, pN3 = lymph node metastases to contralateral or supraclavicular lymph nodes, pNX = evaluation of lymph nodes was not possible), presence of distant metastasis (pM1 = distant metastases, pMX = no information on distant metastases)—according to WHO classification 2015; SqCC, squamous cell carcinoma; TTF-1, thyroid transcription factor 1.