Table 2.

Anticancer effect of quercetin (QT) nanoparticles in in vivo studies.

Nanomaterial Type	Cancer Type/Effect	Study Type	Reference
PEG poly(ethylene glycol)	MELANOMA inhibition of tumour growth (B16F10 melanoma cells)	Animal model (mice)	Dora C. L. et al., 2016 [48]
PEG- phosphatidylethanolamine	LUNG CANCER anticancer activity in the A549 lung cancer cells	Animal model (mice)	Tan B. J. et al., 2012 [9]
PEG-liposomal polyethylene glycol-liposomal	OVARIAN CANCER induction of apoptosis and inhibition of angiogenesis	Animal model (mice)	Long Q. et al., 2013 [49]
TPP-PEG Triphenylphosphine quercetin nanoparticles poly(ethylene glycol)	MITOCHONDRIA-TARGETED TUMOUR THERAPY (MCF-7, A459 and HepG2 cells)	Animal model (mice)	Xing L. et al., 2017 [36]
DSPE-MPEG 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethylene glycol)	PROSTATE CANCER apoptosis induction of human androgen-independent PC-3 cells increased drug accumulation at the tumour site and superior anticancer activity	Animal model (mice)	Zhao J. et al., 2016 [50]
PLGA (poly(lactic co-glycolic acid) nanoparticles	HEPATOCELLULAR CARCINOMA protection of the mitochondrial membrane of the liver from carcinoma mediated prevention of the cytochrome C expression in the liver	Animal model (rats)	Ghosh A. et al., 2012 [42]
PLGA-TMX (poly(lactic co-glycolic acid) tamoxifen	BREAST CANCER oral administration efficiently controlled the tumour angiogenesis, normalized levels of the markers (MMP-2 and MMP-9) in MCF-7 cells	Animal model (rats)	Jain A. K. et al., 2013 [10]
RT-PLGA (poly(lactic co-glycolic acid) nanoparticles of rutin	HEPATOCELLULAR CARCINOMA reduced incidence of hepatic nodules, necrosis formation, infiltration of inflammatory cells, blood vessel inflammation and cell swelling	Animal model (rats)	Pandey P. et al., 2018 [45]
QT-loaded PLGA-TPGS (QPTN) poly-(dl-lactic-co-glycolic acid)-D-α-tocopherol polyethylene glycol succinate	LIVER CANCER suppression of the tumour growth HepG2 and HCa-F cells	Animal model (mice)	Guan X. et al., 2016 [46]
MPEG-PCL monomethoxy poly(ethylene glycol)-poly(ε-caprolactone)	OVARIAN CANCER inhibition of the growth of A2780S ovarian cancer cells through the mitochondrial apoptotic pathway	Animal model (mice)	Gao X. et al., 2012 [51]
	COLORECTAL CANCER improved apoptosis induction and inhibition of cell growth in CT26 cells	Animal model (mice)	Xu G. et al., 2015 [11]
GPSLN GeluPearl comprising of Precirol ATO 5 nanoparticles	MELANOMA reduced lung colonization and enhanced anti-metastatic activity against B16F10 melanoma cells	Animal model (mice)	Jain A. S. et al., 2013 [53]
PLA poly (dl-lactide-co-glycolide)	HEPATOCELLULAR CARCINOMA restricted development of hepatocarcinogenesis	Animal model (rats)	Mandal A. K. et al., 2014 [43]
MPEG-PLA methoxy poly(ethylene glycol)-poly(lactide)	BREAST CANCER inhibition of tumour growth (mammary cancer T1 cells)	Animal model (mice)	Sharma G. et al., 2015 [52]
Gold-PLA gold-quercetin into poly (dl-lactide-co-glycolide) nanoparticles	CERVICAL CANCER induced apoptosis, autophagy and anti-proliferation via Janus kinase 2 suppression	Animal model (mice)	Luo C. L. et al., 2016 [55]
	NEUROGLIOMA induced autophagy and apoptosis in human neuroglioma U87 cells through activation LC3/ERK/Caspase-3 and suppression of AKT/mTOR signaling pathway	Animal model (mice)	Lou M. et al., 2016 [39]
	HEPATOCELLULAR CARCINOMA inactivation of caspase/Cyto-c pathway, suppression of AP-2β/telomerase reverse transcriptase hTERT, inhibition of NF-κB/cyclooxygenase 2 COX-2 and Akt/ERK1/2 signaling pathways	Animal model (mice)	Ren K. W. et al., 2017 [44]
Freeze-dried polymeric micelles	GLIOMA cytotoxic effect on C6 glioma cells	Animal model (mice)	Wang G. et al., 2016 [40]
SPC-CHOL soybean phosphatidylcholine-cholesterol	CERVICAL CANCER in vitro anti-tumour efficacy to Hela cells in vivo inhibition effect on U14 cells	Animal model (mice)	Li J. et al., 2017 [41]
PVP poly (vinyl pyrrolidone)	BREAST CANCER antioxidative activity and efficient photothermal killing effect to cancer 4T1 cells	Animal model (mice)	Tang S. H. et al., 2019 [38]