Table 5.

Anticancer effect of apigenin nanoparticles in in vivo studies.

Nanomaterial Type	Cancer Type/Effect	Study Type	Reference
PLGA	SKIN CANCER A375 cells reduction in markers of proliferative activity increased ROS production and mitochondrial-induced apoptosis	Animal model (mice)	Das S. et al., 2013 [74]
	HEPATOCELLULAR CARCINOMA inhibition effect on cancer cells HepG2 and Huh-7 cells	Animal model (rats)	Bhattacharya S. et al., 2018 [75]
MSN mesoporous silica nanoparticles	improved solubility, dissolution, and bioavailability after oral application	Animal model (rats)	Huang Y., et al., 2019 [76]