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. 2020 Oct 16;216:107706. doi: 10.1016/j.pharmthera.2020.107706

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© 2020 Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Artemisinins: multiple modes of action against cancer CDK2/4/6; Cyclin dependent kinase 2/4/6:mTOR; mammalian target of rapamycin: EGFR;epidermal growth factor: HIF---1α; Hypoxia Inducible Factor 1 alpha:VEGF; Vascular endothelial growth factor: KDR/flk---1;kinase insert domain receptor MMP2; Matrix Metallopeptidase 2: TIMP---2; Tissue inhibitor of metalloproteinases 2: NCAM; Neural Cell Adhesion Molecule: IL---6;interleukin---6: IL---1β; Interleukin---1β: TNF---α; Tumour necrosis factor---α: TGF---β1; Transforming growth factor beta 1: NF---κB; nuclear factor kappa---light---chain--- enhancer of activated B cells: MIP---2; Macrophage Inflammatory Protein 2: PGE2; Prostaglandin E2: NO;Nitric Oxide.