Table 1.
Phagocytic receptors and their ligands.
| Receptors | Ligands | References |
|---|---|---|
|
Pattern-recognition receptors
(PRRs) |
||
| Dectin-1 | Polysaccharide derived from some yeast cells | [17,18,19,20] |
| DC-SIGN | Mannosyl glycans and fucosylated glycans derived from viruses, bacteria, and fungi | [21,22] |
| Lipoarabinomannan | [23] | |
| Mincle | Trehalose-6,6′-dimycolate (TDM), Sin3-associated protein 130 (SAP130) | [24,25,26] |
| MCL | Trehalose-6,6′-dimycolate (TDM), fungal β-glucan | [27,28] |
| CD14 | LPS-binding protein (LBP) | [29] |
| Mannose receptor | Mannan | [30,31] |
| SR-A | LPS derived from gram-negative bacteria or some gram-negative bacteria | [32] |
| CD36 | Plasmodium falciparum-infected erythrocytes | [33] |
| MARCO | Various bacteria and oxidized lipids | [34,35,36] |
| Opsonic receptors | ||
| FcγRI (CD64) | IgG1, IgG3, IgG4 | [37] |
| FcγRII (CD32a) | IgG3, IgG1, IgG | |
| FcγRIII (CD16) | IgG | |
| CR1 (CD35) | C3b, C4b, iC3b | [38] |
| CR2 (CD21/CD21L) | C3d, C3dg, iC3b | |
| CR3 (αMβ2, Mac-1, CD11b/CD18) |
iC3b, C3dg, C3d, ICAM-1, ICAM-2, LPS, fibronectin, oligonucleotides, zymosan | |
| CR4 (CD11c/CD18) | iC3b, C3dg, C3d | |
| CRIg | C3b, iC3b, C3c | |
| Receptors for apoptotic cells | ||
| Integrin αVβ3 | Phosphatidylserine Phosphatidylserine Phosphatidylserine Phosphatidylserine Phosphatidylserine |
[39] [39] |
| TIM-1 | ||
| TIM-4 | ||
| BAI1 | ||
| Stabilin-2 | ||
| CD36 | OxLDL-like molecules | [40,41] |
| CD14 | Phosphatidylserine | [42] |
| CD94 | C1q on apoptotic cells | [43] |