Fig. 1.

Manhattan plot illustrating the outcomes of the PheWAS analysis of the smoking intensity GRS in ever smokers. The red line indicates the FDR threshold (p<0.0025). Y-axis is minus log transformed P-value of the association between smoking intensity genetic risk score (GRS) and disease outcomes; the X-axis provides the list of labels of 17 diseases groups. Arrows pointing up indicate that the smoking intensity GRS is associated with increased odds of disease. Arrows pointing down indicate that the smoking intensity GRS is associated with decreased odds of disease.