Skip to main content
. 2020 May 20;10(9):1634–1645. doi: 10.1016/j.apsb.2020.05.002

Figure 2.

Figure 2

Hyperexcitability and enhanced synaptic transmissions of pyramidal and stellate neurons from Il-4−/− mice. (A) Morphology of pyramidal neurons in the motor cortex (M1) layer II/III labeled with neurobiotin. (B) Representative traces for neuronal firings by whole-cell current clamp recordings of Il-4+/+ and Il-4−/− pyramidal neuron. (C) The comparison of fired action potential numbers (AP No.) between of Il-4−/− and Il-4+/+ pyramidal neurons. (D) The resting membrane potentials (RMP) of Il-4+/+ and Il-4−/− pyramidal neurons. (E) Representative traces for miniature excitatory postsynaptic currents (mEPSCs) by voltage-clamp recordings of Il-4+/+ and Il-4−/− pyramidal neurons. (F) Increased frequency of mEPSCs with a cumulative probability of shorter inter-event intervals. (G) In Il-4−/− pyramidal neurons. (H) Morphology of a stellate neuron in mEC layer II for patch-clamp recordings. (I) The representative traces for neuronal firings of recordings of Il-4+/+ and Il-4−/− stellate neurons. (J) Comparison of fired AP No. and RMP (K) between of Il-4+/+ and Il-4−/− stellate neurons. (L) Representative traces for mEPSCs in Il-4+/+ and Il-4−/− stellate neurons. (M) Increased frequency of mEPSCs with a cumulative probability of shorter inter-event intervals. (N) in Il-4−/− stellate neurons. Data are expressed as the mean ± SEM; n indicates the number of cells recorded, ∗P < 0.05, and ∗∗∗P < 0.001 versus Il-4+/+ group.