Table 1.

Salient features of exosomes from young vs. aging individuals.

Exosomes from Young Individual	Exosomes from Aged Individual
Normal levels of EV	Increased EV secretion
Exosomes do not have an adverse effect on tissue microenvironment	Exosomes from senescent cells are detrimental to the tissue microenvironment
Exosomal cargo do not result in any pathological changes	Exosomal cargo can mediate/accelerate pathological changes
Normal expression of miRNAs and proteins	Differential expression of miRNAs and proteins could act as biomarkers for diagnosis of age-related pathologies