Table 2.
Differentially expressed exosomal miRNAs as biomarkers for aging.
| Exosomal miRNA | Derived From | Function | Reference |
|---|---|---|---|
| miR-96, miR-182, miR-183 | Bone marrow | Increase senescence in bone marrow cells | [101] |
| miR-24-3p | Saliva | Inflammatory cytokine and chemokine gene regulation | [102] |
| miR-151a-3p, miR-181a-5p, miR-1258, miR-29b, miR-106b, miR-130b. miR-142-5p, miR-340 | Serum | Down-regulated with aging | [104] |
| miR-92a, miR-222, miR-192 | Serum | Up-regulated with aging | [105] |
| miR-15 | Urine | Differentially expressed in diabetic nephropathy | [106] |
| miR-15a-3p | Blood | Up-regulated in diabetic patients | [107] |
| miR-125a-5p, miR-23a-3p, miR-375 | Blood | Differentially expressed in Alzhemier’s Disease | [110] |
| hsa-miR-203-3p, hsa-miR-4482-3p,hsa-miR-44366b-3p | COVID-19 patients | Target S protein involved in viral replication | [112] |
| hsa-miR-190a-5p | COVID-19 patients | Target ORF6 involved in immune suppression | [112] |