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Origin, function, and heterogeneity of CAFs. This is a schematic representation of the (A) different cell origins of CAFs, (B) various functions of CAFs, and (C) heterogeneity of CAFs as found in different organs based on current studies. The yellow squares in (C) indicates yet un-characterized CAF subtype for that particular tumor. Abbreviations: FA, functional assay; FACs fluorescence-associated cell sorting; scRNA-seq, single-cell RNA sequencing.
