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. 2020 Aug 25;12(9):2406. doi: 10.3390/cancers12092406

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Molecular mechanisms of lncRNAs involved in platinum resistance. The lncRNA ZFAS1 enhances cisplatin resistance through regulating the miR-150-5p/SP1/copper transporter 1 (CTR1) axis. Nuclear-enriched abundant transcript 1 (NEAT1) ameliorates platinum resistance via upregulating epigallocatechin-3-gallate (EGCG)-induced CTR1 expression. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and LINC00152 promote cisplatin resistance through activating MRP1. Homeobox transcript antisense RNA (HOTAIR) enhances platinum resistance via activating autophagy and Wnt/β catenin-induced epithelial–mesenchymal transition (EMT). The lncRNA H19 induces platinum resistance via enhancing the expression of nuclear factor erythroid 2 (NRF2) and glutathione (GSH), thereby preventing reactive oxygen species (ROS)-induced cytotoxicity. Moreover, H19 promotes platinum resistance by activating transcription factors involved in EMT.