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. 2020 Aug 25;12(9):2406. doi: 10.3390/cancers12092406

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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lncRNAs regulate platinum resistance via modulating DNA-damage-induced apoptosis. Growth arrest-specific transcript 5 (GAS5) mitigates cisplatin resistance via inhibiting PARP1-induced DNA repair. Colon cancer-associated transcript 1 (CCAT1) promotes platinum resistance through sponging miR-454, thereby activating survivin and inhibiting apoptosis. HOTAIR exacerbates platinum resistance through activating NF-κB, leading to increased expression of survival genes. lncRNAs promoter of CDKN1A antisense DNA damage activated RNA (PANDAR), E2F-mediated proliferation enhancing lncRNA (EPEL), and HOTAIR induce platinum resistance via inhibiting p53-induced apoptosis, while plasmacytoma variant translocation 1 (PVT1) inhibits platinum resistance via promoting p53-induced apoptosis.